SH3 & multiple ankyrin repeat domains protein 2; Shank2; cortactin-binding protein 1; cortBP1; proline-rich synapse-associated protein 1 (SHANK2, CORTBP1, KIAA1022, PROSAP1)

Function

• seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type & metabotropic glutamate receptors, & the actin-based cytoskeleton
• may play a role in the structural & functional organization of the dendritic spine & synaptic junction
• interacts with CCTN/cortactin SH3 domain, DLGAP1/GKAP &
• alpha-latrotoxin receptor 1
• part of a complex with DLG4/PSD-95 & DLGAP1/GKAP
• interacts with GRID2, SLC9A3, CFTR & PLCB3
• interacts with DBNL (putative)
• interacts with DNM2
• interacts with BAIAP2

Structure

• the PDZ domain is required for interaction with GRID2, PLCB3, CFTR & SLC9A3 (putative)
• belongs to the SHANK family
• contains 1 PDZ domain (DHR domain)
• contains 1 SAM (sterile alpha motif) domain
• contains 1 SH3 domain

Compartment

• cytoplasm (putative)
• cell junction
• synapse, postsynaptic cell membrane, postsynaptic density (putative)

Alternative splicing

• named isoforms=4
• additional isoforms seem to exist

Expression

• isoform 3 is present in epithelial colonic cells (at protein level)

More general terms

• SH3 & multiple anykrin repeat domains (Shank) protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22941
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22941
• OMIM: https://mirror.omim.org/entry/603290
• UniProt: http://www.uniprot.org/uniprot/Q9UPX8.html