disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)

Function

• part of the postsynaptic scaffold in neuronal cells
• interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 & AIP1
• interacts with the PDZ domain of SHANK1, SHANK2 & SHANK3
• found in a complex with DLG4 & SHANK1, SHANK2 or SHANK3
• found in a complex with DLG4 & BEGAIN
• interacts with DYL2 & LRFN1 (putative)

Structure

belongs to the SAPAP family

Compartment

• cell membrane, cell junction
• synapse, postsynaptic cell membrane, postsynaptic density
• found in postsynaptic density of neurons (putative)

Alternative splicing

named isoforms=3

Expression

expressed in brain

More general terms

• scaffold protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9229
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9229
• OMIM: https://mirror.omim.org/entry/605445
• UniProt: http://www.uniprot.org/uniprot/O14490.html