SH3 & multiple ankyrin repeat domains protein 1; Shank1; somatostatin receptor-interacting protein; SSTR-interacting protein; SSTRIP (SHANK1)

Function

• seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-receptors & metabotropic glutamate receptors via complexes with GKAP/PSD-95 & homer, respectively, & the actin-based cytoskeleton
• may play a role in the structural & functional organization of the dendritic spine & synaptic junction
• may homomultimerize via its SAM domain (putative)
• interacts with the C-terminus of SSTR2 via the PDZ domain
• interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 & DLGAP1/GKAP isoforms 1 & 2 (putative)
• binds to DAP-1 through its PDZ domain & to homer through one of its proline-rich regions
• part of a complex with DLG4/PSD-95 & DLGAP1/GKAP (putative)
• interacts with BAIAP2
• May also associate with cortactin
• overexpression in cultured neurons leads to enlargement of dendritic spines

Structure

• belongs to the SHANK family
• contains 6 ANK repeats
• contains 1 PDZ domain (DHR domain)
• contains 1 SAM (sterile alpha motif) domain
• contains 1 SH3 domain

Compartment

• cytoplasm (putative)
• cell junction, synapse, postsynaptic cell membrane, postsynaptic density

Alternative splicing

named isoforms=3

Expression

• expressed in brain particularly in the amygdala, hippocampus, substantia nigra & thalamus
• isoform 2 seems to be expressed ubiquitously

More general terms

• SH3 & multiple anykrin repeat domains (Shank) protein
• oligomerizing protein
• phosphoprotein
• ankyrin repeat domain protein (ANKRD)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50944
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50944
• OMIM: https://mirror.omim.org/entry/604999
• UniProt: http://www.uniprot.org/uniprot/Q9Y566.html