homer protein homolog 1; homer-1 (HOMER1 ,SYN47)

Function

• postsynaptic density scaffolding protein
• WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1, SHANK3
• links GRM1 & GRM5 with ER-associated ITPR1 receptors
• couples GRM1 to PI3 kinase via CENTG1 (putative)
• plasticity at glutamatergic synapses

Structure

• coiled-coil domain mediates self-association
• the WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 & SHANK3
• belongs to the homer family
• contains 1 WH1 domain

Compartment

cytoplasmic, postsynaptic density of neurons

Alternative splicing

named isoforms=3

More general terms

• homer protein

More specific terms

• homer 1A protein
• homer 1B protein
• homer 1C protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9456
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9456
• OMIM: https://mirror.omim.org/entry/604798
• UniProt: http://www.uniprot.org/uniprot/Q86YM7.html