Metabotropic glutamate receptor 5; mGluR5 (GRM5, GPRC1E, MGLUR5)

Function

• receptor for glutamate
• activity is mediated by a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system & generates a Ca+2-activated chloride current
• PPXXF motif binds HOMER1, HOMER2 & HOMER3
• interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 & GRASP

Structure

belongs to the G-protein coupled receptor 3 family

Compartment

cell membrane

Alternative splicing

named isoforms=2

More general terms

• metabotropic glutamate receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2915
• OMIM: https://mirror.omim.org/entry/604102
• UniProt: http://www.uniprot.org/uniprot/P41594.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2915