homer protein homolog 2; homer-2; Cupidin (HOMER2)

Function

• postsynaptic density scaffolding protein
• WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1, SHANK3
• links GRM1 & GRM5 with ER-associated ITPR1 receptors
• plasticity at glutamatergic synapses

Structure

• the WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 & SHANK3
• belongs to the homer family
• contains 1 WH1 domain

Compartment

cytoplasm, postsynaptic density of neurons

Alternative splicing

named isoforms=4

More general terms

• homer protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9455
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9455
• OMIM: https://mirror.omim.org/entry/604799
• UniProt: http://www.uniprot.org/uniprot/Q9NSB8.html