Metabotropic glutamate receptor 1; mGluR1 (GRM1, GPRC1A, MGLUR1)

Function

• receptor for glutamate
• activity is mediated by a G-protein that activates a phosphatidylinositol- Ca+2 second messenger system
• may play role in CNS action of glutamate
  • long-term potentiation in the hippocampus
  • long-term depression in the cerebellum
• interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 & GRASP (putative)

Structure

• homodimer; disulfide-linked
• PPXXF motif in proline rich region binds to EVH1 domain in HOMER1, HOMER2 & HOMER3
• belongs to the G-protein coupled receptor 3 family

Compartment

cell membrane

Alternative splicing

named isoforms=2; alpha, beta

More general terms

• metabotropic glutamate receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2911
• OMIM: https://mirror.omim.org/entry/604473
• UniProt: http://www.uniprot.org/uniprot/Q13255.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2911