long term depression (LTD)
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Introduction
LTD is an activity-dependent synapse-specific decrease in synaptic efficacy. It is long-lasting, persisting for days to weeks.
LTD is a form of neuronal plasticity that may form the basis for forgetting.
Ca+2 influx through NMDA receptors is critical for induction of LTD[1]. In contast to LTP, low levels of intracellular Ca+2 are involved in LTD.[2]
Dephosphorylation of S845 in GluR1 of AMPA receptors may also play a role.[2]
More general terms
Additional terms
References
- ↑ 1.0 1.1 Villarreal et al Nature neurosciences 5:48, 2001
- ↑ 2.0 2.1 2.2 Castellani GC, Quinlan EM, Bersani F, Cooper LN, Shouval HZ. A model of bidirectional synaptic plasticity: From signaling network to channel conductance. Learn Mem. 2005 Jul 18; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/16027175