long term depression (LTD)

From Aaushi
Jump to navigation Jump to search

Introduction

LTD is an activity-dependent synapse-specific decrease in synaptic efficacy. It is long-lasting, persisting for days to weeks.

LTD is a form of neuronal plasticity that may form the basis for forgetting.

Ca+2 influx through NMDA receptors is critical for induction of LTD[1]. In contast to LTP, low levels of intracellular Ca+2 are involved in LTD.[2]

Dephosphorylation of S845 in GluR1 of AMPA receptors may also play a role.[2]

More general terms

Additional terms

References

  1. 1.0 1.1 Villarreal et al Nature neurosciences 5:48, 2001
  2. 2.0 2.1 2.2 Castellani GC, Quinlan EM, Bersani F, Cooper LN, Shouval HZ. A model of bidirectional synaptic plasticity: From signaling network to channel conductance. Learn Mem. 2005 Jul 18; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/16027175