AMPA receptor or alpha glutamate receptor
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Introduction
alpha-Amino-3-hydroxy-5-Methylisoxazole-4-Propionic Acid [AMPA] ionophore-linked receptor
Function
- the AMPA receptor appears to move in & out of synaptic membranes in a dynamic fashion[5]
- endocytosis of AMPA receptors
- may be associated with attenuation of excitatory neurotransmission
- stimulated by synaptic activity, ligand binding & insulin
- dependent on dynamin & phosphorylation/phosphatases
- stimulus for endocytosis determines the fate on the AMPA receptors
- AMPA stimulation leads to a recycling endosome; insulin stimulation leads to degradation?
- potentiated by Zn+2.
- some variants may be somewhat permeable to Ca+2
- both AMPA & kainate are agonists[4]
More general terms
References
- ↑ Choi 1988
- ↑ Manzoni OJ, Finiels-Marlier F, Sassetti I, Blockaert J, le Peuch C, Sladeczek FA. The glutamate receptor of the Qp-type activates protein kinase C and is regulated by protein kinase C. Neurosci Lett. 1990 Feb 5;109(1-2):146-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2156190
- ↑ Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1360717
- ↑ 4.0 4.1 Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994 Mar 3;330(9):613-22. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7905600
- ↑ 5.0 5.1 Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11416187