proline-rich region

Introduction

Proline-rich regions may serve as binding sites for SH3 (src-homology 3) domains. They may also serve as sites for phosphorylation by proline-directed protein kinases. Phosphorylation may alter the binding with SH3-domains.

The proline-rich regions may also contain a motif PPXXF which serves to bind the EVH1 domain of homer.

More general terms

• specific amino acid-enriched region (low complexity region)
• binding site

More specific terms

• proline-rich transcriptional activation domain (TAD)

Additional terms

• src homology 3 [SH3] domain