somatostatin receptor 2; SS2R; SRIF-1 (SSTR2)

Function

• receptor for somatostatin-14 & somatostatin-28.
• coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
• additionally, stimulates phosphotyrosine phosphatase & PLC via G proteins (both pertussis toxin sensitive & insensitive)
• in RIN-5F cells, inhibits Ca+2 entry by suppressing voltage-dependent Ca+2-channels
• C-terminus interacts with SHANK1 PDZ domain

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=2 (SSTR2A, SSTR2B)

Expression

• cerebrum & kidney
• lesser expression in jejunum, colon & liver

More general terms

• somatostatin receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6752
• OMIM: https://mirror.omim.org/entry/182452
• UniProt: http://www.uniprot.org/uniprot/P30874.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6752