phospholipase C-beta 3 (PLCB3, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3)

Function

• production of the second messenger molecules diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
• interacts with SHANK2 (putative)

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
                   <-->
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactor: Ca+2

Structure

• contains 1 C2 domain
• contains 1 PI-PLC X-box domain
• contains 1 PI-PLC Y-box domain

Compartment

peripheral membrane

More general terms

• phospholipase C-beta

Database

• UniProt: http://www.uniprot.org/uniprot/Q01970.html
• OMIM: https://mirror.omim.org/entry/600230
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5331