phospholipase C-beta
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Function
- nuclear activity stimulated by IGF-1 in 3T3 cells
- activation precedes PKC translocation to nucleus
- calpain hydrolyzes 150 kD isoform to 100 kD form
- PLC-beta is insensitive to inhibition by profilin
More general terms
More specific terms
- phospholipase C-beta 1 (PLCB1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1, PLC-154, KIAA0581)
- phospholipase C-beta 2 (PLCB2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2)
- phospholipase C-beta 3 (PLCB3, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3)
- phospholipase C-beta 4 (PLCB4, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4)
References
- ↑ Anderson D, Koch CA, Grey L, Ellis C, Moran MF, Pawson T. Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science. 1990 Nov 16;250(4983):979-82. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2173144
- ↑ Goldschmidt-Clermont PJ, Kim JW, Machesky LM, Rhee SG, Pollard TD. Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. Science. 1991 Mar 8;251(4998):1231-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1848725
- ↑ Martelli AM, Gilmour RS, Bertagnolo V, Neri LM, Manzoli L, Cocco L. Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells. Nature. 1992 Jul 16;358(6383):242-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1321347
- ↑ Liscovitch M. Crosstalk among multiple signal-activated phospholipases. Trends Biochem Sci. 1992 Oct;17(10):393-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455508