phospholipase C-beta 4 (PLCB4, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4)

Function

• production of the second messenger molecules diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
• role in retina signal transduction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
                 <-->
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactor: Ca+2

Structure

• contains 1 C2 domain
• contains 1 PI-PLC X-box domain
• contains 1 PI-PLC Y-box domain

Alternative splicing

named isoforms=2

Expression

preferentially expressed in the retina

More general terms

• phospholipase C-beta

Database

• OMIM: https://mirror.omim.org/entry/600810
• UniProt: http://www.uniprot.org/uniprot/Q15147.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5332