calpain
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Introduction
Calpains are a superfamily of related proteins
Function
- some have been shown to function as intracellular Ca+2- dependent cysteine proteases
- role in cytosolic/nuclear proteolytic signalling
Structure
- variable large (80 kD) catalytic subunit & an invariant small regulatory (30 kD) subunit
More general terms
More specific terms
- calpain-1 or calcium-activated neutral protease-mu type
- calpain-2 or calcium-activated neutral protease-M type
- calpain-3
- calpain-5
- calpain-6
- calpain-7
- calpain-8; stomach-specific M-type calpain; new calpain 2; nCL-2 (CAPN8, NCL2)
- calpain-9
- calpain-10
- calpain-11
- calpain-12 (CAPN12)
- calpain-13 (CAPN13)
- calpain-14 (CAPN14)
- calpain-15; small optic lobes homolog (SOLH, CAPN15)
References
- ↑ OMIM https://mirror.omim.org/entry/604822
- ↑ Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol. 2001 Aug;2(8):589-98. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11483992