phospholipase C-beta 1 (PLCB1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1, PLC-154, KIAA0581)
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Function
- mediates production of the second messenger molecules diacylglycerol (DAG) & inositol 1,4,5-trisphosphate (IP3)
- activated by all members of the Gq-alpha family
- activated by Gq-alpha & G11-alpha
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
<-->
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactor: Ca+2
Structure
Alternative splicing
named isoforms=2
More general terms
References
- ↑ Taylor SJ, Chae HZ, Rhee SG, Exton JH. Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins. Nature. 1991 Apr 11;350(6318):516-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1707501
- ↑ Wu D et al G protein-coupled signal transduction pathways for interleukin-8. Science 261:101 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8316840
- ↑ Boguski MS & McCormick F Proteins regulating Ras and its relatives. Nature 366:643 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8259209
- ↑ Atlas of Genetics & cytogenetics in oncology & Haematology http://atlasgeneticsoncology.org/Genes/PLCB1ID41742ch20p12.html
- ↑ UniProt http://www.uniprot.org/uniprot/Q9NQ66.html