phospholipase C-beta 2 (PLCB2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2)

^[1]^[2]^[3]

Function

production of the second messenger molecules diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
most effectively mediated by G16-alpha
activated by G beta-gamma^[1]
interacts with RAC1

1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H2O
                  <-->
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactor: binds 1 Ca+2 per subunit

↑ ^1.0 ^1.1 Wu D et al G protein-coupled signal transduction pathways for interleukin-8. Science 261:101 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8316840
↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/Genes/PLCB2ID41743ch15q15.html
↑ UniProt http://www.uniprot.org/uniprot/Q00722.html