insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
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Function
- structurally & functionally related to insulin but with a much higher growth-promoting activity
- 85% bound in molecular complex with IGF-binding protein 3 & acid labile subunit glycoprotein.
- may enhance growth of tumors.[3]
- may be a physiological regulator of glucose transport & glycogen synthesis in osteoblasts
Structure
belongs to the insulin family
Compartment
- plasma
- secreted by liver in response to growth hormone Alternate splicing:
- forms IGF-1A & IGF-1B
- named isoforms=4
Expression
- secreted by liver in response to growth hormone
Pathology
- IGF1 deficiency is an autosomal recessive disorder
- low plasma IGF-1 levels predicts life expectancy in exceptionally long-lived women & persons of either gender with history of cancer[8]
Pharmacology
- NOT effective as a pharmaceutical agent[2]
More general terms
More specific terms
Additional terms
- insulin-like growth factor (IGF)-1 or somatomedin C in serum
- insulin-like growth factor [IGF]-1 receptor (somatomedin-C receptor, CD221, IGF1R)
References
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908
- ↑ 2.0 2.1 Solomon DH, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- ↑ 3.0 3.1 LeRoith D IGF-1, Cancer and Aging Aging: Mechanisms and Prevention 34th Annual Meeting of the American Aging Association June 3-6, 2005, Oakland CA
- ↑ UniProt http://www.uniprot.org/uniprot/P05019.html
- ↑ SHMPD; Note: Singapore human mutation andpolymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/igf1/
- ↑ Wikipedia; Note: insulin-like growth factor 1 entry http://en.wikipedia.org/wiki/insulin-like_growth_factor_1
- ↑ 8.0 8.1 Milman S, Atzmon G, Huffman DM et al Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014 Aug;13(4):769-71. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24618355 Free PMC Article