insulin-like growth factor [IGF]-1 receptor (somatomedin-C receptor, CD221, IGF1R)
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Function
- binds insulin-like growth factor 1 (IGF1) with a high affinity & IGF2 with a lower affinity
- tyrosine-protein kinase activity actvates IGF1-stimulated downstream signaling cascade
- interacts with PIK3R1 & with the PTB/PID domains of IRS1 & SHC1 in vitro when autophosphorylated on Tyr
- autophosphorylation activates the kinase activity
- cytoplasmic domain of the beta subunit is autophosphorylated on Tyr in response to insulin-like growth factor 1 (IG1)
- phosphorylation of Tyr-980 is required for IRS1- & SHC1- binding
Structure
- tetramer of 2 alpha & 2 beta chains linked by disulfide bonds
- alpha chains contribute to the formation of the ligand-binding domain
- beta chain carries the kinase domain
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 3 fibronectin F3 modules
- contains 1 protein kinase domain
Compartment
membrane
Expression
expressed in a variety of tissues
Pathology
- defects in IGF1R may be a cause in some cases of IGF1 resistance
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P08069.html
- ↑ Wikipedia; IGF-1 receptor entry http://en.wikipedia.org/wiki/IGF-1_receptor
- ↑ Nishibe S et al Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proc Natl Acad Sci U S A. 1990 Jan;87(1):424-8. Erratum in: Proc Natl Acad Sci U S A 1990 Apr;87(8):3253. Kim JJ [corrected to Kim JW]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2153302
- ↑ Yarden Y, Ullrich A. Growth factor receptor tyrosine kinases. Annu Rev Biochem. 1988;57:443-78. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/3052279