insulin-like growth factor (IGF)-1 or somatomedin C in serum

Indications

• diagnosis of & assessment of severity of acromegaly
• assessement of response of dwarfism to growth hormone therapy#
• assessment of effectiveness of nutritional repletion
  • may be superior to prealbumin

# children with low levels of IGF-1 may need growth hormone stimulation test to establish the diagnosis of growth hormone deficiency

Reference interval

• 135-440 ng/mL, age = 26-85 years

• Male: 202-433 ng/mL, age = 19-25 years
• Female: 231-550 ng/mL, age = 19-25 years

• Male: 134-836 ng/mL, age = 15-18 years
• Female: 152-860 ng/mL, age = 15-18 years

• Male: 165-616 ng/mL, age = 13-14 years
• Females : 286-660 ng/mL, age = 13-14 years

• Male: 136-440 ng/mL, age = 11-12 years
• Female: 191-462 ng/mL, age = 11-12 years

• Male: 136-385 ng/mL, age = 7-10 years
• Female: 123-396 ng/mL, age = 7-10 years

• Male: 16-288 ng/mL, age = 3-6 years
• Female: 70-316 ng/mL, age = 3-6 years

• Male: 31-160 ng/mL, age = 1-2 years
• Female: 11-206 ng/mL, age = 1-2 years

amniotic fluid (< 12 weeks): undetectable

* Levels are higher in pregnancy

Increases

• acromegaly

Decreases

• high-dose estrogens
• dwarfism
• hypopituitarism
• hypothyroidism
• malnutrition
  • after refeeding, high levels of growth hormone decrease & low levels of IGF-1 increase
• anorexia
• emotional deprivation syndrome
• cirrhosis of the liver
• sarcopenia

Specimen

• serum
• freeze immediately
• stable for 30 days

More general terms

• IGF1 in serum/plasma/blood

Additional terms

• acromegaly
• growth hormone (GH) stimulation test
• growth hormone (somatotropin) in serum
• insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)

Patient information

IGF1 in serum patient information