IGF-binding protein complex acid labile subunit; ALS (IGFALS, ALS)

Function

• role in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion
• forms a ternary complex of about 140 to 150 kD with IGF-1 or IGF-2 & IGFBP-3 (IGF1-IGFBP3-ALS)

Structure

• contains 19 LRR repeats (leucine-rich repeats)
• contains 1 LRRCT domain
• contains 1 LRRNT domain

Compartment

secreted, extracellular space

Expression

plasma

More general terms

• insulin-like growth factor [IGF]-binding protein
• glycoprotein
• leucine-rich repeat-containing protein (LRRC)

Component of

• IGF-1/IGF binding protein 3/acid-labile subunit glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3483
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3483
• OMIM: https://mirror.omim.org/entry/601489
• UniProt: http://www.uniprot.org/uniprot/P35858.html