drebrin-like protein (SH3 domain-containing protein 7, drebrin-F, cervical SH3P7, HPK1-interacting protein of 55 kD, HIP-55, cervical mucin-associated protein, DBNL, CMAP, SH3P7, PP5423)

Function

• actin-binding adapter protein
• common effector of antigen receptor-signaling pathways in leukocytes (putative)
• association with dynamin suggests that it may connect the actin cytoskeleton to endocytic function
• component of the 'immunological synapse' that regulates T-cell activation by bridging TCRs & the actin cytoskeleton to gene activation & endocytic processes
• binds to F-actin but is not involved in actin polymerization, capping or bundling
• does not bind G-actin
• interacts with SHANK2 & SHANK3 via SH3 domain
• interacts with FGD1, dynamin, MAP4K1
• degraded by caspases during apoptosis

Structure

• contains 1 ADF-H domain
• contains 1 SH3 domain

Compartment

• cytoplasm; cytoskeleton
• cortical cytoskeleton
• associates with lamellipodial actin

Alternative splicing

named isoforms=3

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• drebrin; drebrin-1; developmentally-regulated brain protein (DBN1, D0S117E)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UJU6.html