drebrin; drebrin-1; developmentally-regulated brain protein (DBN1, D0S117E)

Function

• actin-binding protein highly enriched in dendritic spines
• regulates dendritic spine morphogenesis prior to formation of postsynaptic densities
• drebrin-1 recruits PSD-95 to the post-synaptic density.
• forms clusters in dendritic filopodia
• drebrins might play some role in cell migration, extension of neuronal processes & plasticity of dendrites
• binds F-actin

Structure

contains 1 ADF-H domain

Compartment

• cytoplasm, highly enriched in dendritic spines

Alternative splicing

• named isoforms=2; drebrin E (embryonic form) & drebrin A (adult form)
• drebrin A is neuron-specific

Expression

• brain, neurons
• also found in the heart, placenta, skeletal muscle, kidney & pancreas

Pathology

• a decrease in drebin 1 has been reported in brains of patients with Alzheimer's disease & Down syndrome.

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• neuronal PAS domain-containing protein 4 (neuronal PAS4, HLH-PAS transcription factor NXF, NPAS4, NXF)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1627
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1627
• OMIM: https://mirror.omim.org/entry/126660
• UniProt: http://www.uniprot.org/uniprot/Q16643.html