neuronal PAS domain-containing protein 4 (neuronal PAS4, HLH-PAS transcription factor NXF, NPAS4, NXF)

Function

• transcriptional activator in the presence of ARNT
• activates CME (CNS midline enhancer) element & expression of drebrin gene
• DNA binding requires dimerization with another bHLH protein
• forms a heterodimer with ARNT

Structure

• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 PAC domain (PAS-associated C-terminal domain)
• contains 2 PAS domains (PER-ARNT-SIM domains)

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

expressed in brain

More general terms

• DNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/608554
• UniProt: http://www.uniprot.org/uniprot/Q8IUM7.html