mitogen activated protein kinase kinse kinase kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; hematopoietic progenitor kinase-1 (MAP4K1, HPK1)

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Function

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

Expression

More general terms

References

  1. OMIM https://mirror.omim.org/entry/601983
  2. Zhou G et al. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. J Biol Chem 274:13133-8, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10224067
  3. Sawasdikosol S et al Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2-induced fos gene transcription. Blood 101(9):3687-9, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12522005
  4. UniProt http://www.uniprot.org/uniprot/Q92918.html

Database