mitogen activated protein kinase kinse kinase kinase 1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; hematopoietic progenitor kinase-1 (MAP4K1, HPK1)
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Function
- may play a role in the response to environmental stress
- upstream activator of the MEKK/JNK/SAPK signaling pathway
- role in hematopoietic lineage decisions & growth regulation (putative)
- involved in TGF-beta signaling pathway via TAK1 (MAP3K7) & JNKs
- interacts with MAP3K1
ATP + a protein <--> ADP + a phosphoprotein
Cofactor: Mg+2
Structure
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
- contains 1 CNH domain
- contains 1 protein kinase domain
Expression
- expressed primarily in hematopoietic organs, including bone marrow, spleen & thymus
- also expressed at very low levels in lung, kidney, mammary glands & small intestine
More general terms
References
- ↑ OMIM https://mirror.omim.org/entry/601983
- ↑ Zhou G et al. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. J Biol Chem 274:13133-8, 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10224067
- ↑ Sawasdikosol S et al Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2-induced fos gene transcription. Blood 101(9):3687-9, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12522005
- ↑ UniProt http://www.uniprot.org/uniprot/Q92918.html