mitogen-activated protein kinase kinase kinase 1 (MAP3K1, MAPK/ERK kinase kinase 1, MEKK1, MAPKKK1, MEKK)

Function

• component of a protein kinase signal transduction cascade
• activates the ERK & JNK kinase pathways by phosphorylation of MAP2K1 & MAP2K4
• activates CHUK & IKBKB, the central protein kinases of the NF-kappa-B pathway
• binds both upstream activators & downstream substrates in multimolecular complexes through its N-terminus
• oligomerizes after binding MAP4K2 or TRAF2
• interacts with AXIN1
• activated by autophosphorylation on Thr-1402 & Thr-1414 following oligomerization
• autophosphorylated (putative)

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 protein kinase domain
• contains 1 RING-type Zn+2 finger
• contains 1 SWIM-type Zn+2 finger

More general terms

• MAP3K/MEKK
• ring finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q13233.html
• OMIM: https://mirror.omim.org/entry/600982
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4214