mitogen activated protein kinase kinse kinase kinase 2 (MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, germinal center kinase, GC kinase, Rab8-interacting protein, B lymphocyte serine/threonine protein kinase, MAP4K2, GCK, RAB8IP)

Function

• enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition & lead to activation following autophosphorylation
• may play a role in regulation of vesicle targeting or fusion
• interacts with TRAF2, MAP3K1 & RAB8A

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 CNH domain contains 1 protein kinase domain

Compartment

• cytoplasm (putative)
• basolateral cell membrane, peripheral membrane
• Golgi

Expression

• highly expressed in germinal center but not mantle zone B-cells
• also expressed in lung, brain & placenta > other tissues

More general terms

• mitogen activated protein kinase kinse kinase kinase

Database

• OMIM: https://mirror.omim.org/entry/603166
• UniProt: http://www.uniprot.org/uniprot/Q12851.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5871