TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor-associated protein 3 (TRAF2, TRAP3)
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Function
- adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases
- thought to transmit signal of TNF-receptor 2
- association to the receptor is also mediated by the interaction with TRADD
- mediates activation of NF-kappa-B & JNK & is involved in apoptosis
- the TRAF1/TRAF2 complex recruits apoptotic suppressors BIRC2 & BIRC3 to TNFRSF1B/TNFR2
- seems to be involved in IL-15 signaling
- ubiquitinated; mediated by SIAH2 & leading to its subsequent proteasomal degradation
- not ubiquitinated by SIAH1
- homotrimer (probable)
- heteromer with TRAF1
- binds to TNFRSF1B/TNFR2, TNFRSF4 & TNFRSF5/CD40
- associates with CD27, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, IL15RA, TANK/ITRAF, RIPK2, TNIK, MAP3K14, MAP3K5, MAP3K1, MAP4K2, CDK9, CSK, & TRAF-interacting protein TRAIP & TRAF & TNF receptor-associated protein TTRAP
- interacts with TNFAIP3 & TRPC4AP
- interacts with PEG3 (putative)
- binds to TRADD
- interacts with BIRC2 & BIRC3 N-terminus
- interacts with CYLD & TBK1
- interacts with MAVS/IPS1
- interacts with CASP8AP2 & USP48
- interacts with DAB2IP
- interacts with NFATC2IP & with HIVEP3 (putative)
Structure
- the coiled coil domain mediates homo- & hetero- oligomerization
- the MATH/TRAF domain binds to receptor cytoplasmic domains
- contains 1 MATH domain
- contains 1 RING-type Zn+2 finger
- contains 2 TRAF-type Zn+2 fingers
Compartment
Alternative splicing
named isoforms=2
More general terms
References
- ↑ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533327
- ↑ Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996 Jan 26;84(2):299-308. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8565075
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7186
- ↑ UniProt http://www.uniprot.org/uniprot/Q12933.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/traf2/
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7186
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7186
- OMIM: https://mirror.omim.org/entry/601895
- UniProt: http://www.uniprot.org/uniprot/Q12933.html
- Kegg: http://www.genome.jp/dbget-bin/www_bget?