tumor necrosis factor receptor superfamily member 14; Herpesvirus entry mediator A; tumor necrosis factor receptor-like 2; TR2 (TNFRSF14, HVEA, HVEM, UNQ329/PRO509)

Function

• receptor for BTLA
• receptor for
  • TNFSF14/LIGHT
  • homotrimeric TNFSF1/lymphotoxin-alpha
• role in lymphocyte activation
• interacts with TRAF2, TRAF3 & TRAF5

Structure

• N-glycosylated
• contains 3 TNFR-Cys repeats

Compartment

membrane

Expression

• widely expressed
• highest expression in lung, spleen & thymus

Pathology

• role in HSV pathogenesis
• enhances entry of several wild-type HSV strains of both serotypes into CHO cells
• mediates HSV entry into activated human T-cells

More general terms

• tumor necrosis factor [TNF] receptor family

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8764
• OMIM: https://mirror.omim.org/entry/602746
• UniProt: http://www.uniprot.org/uniprot/Q92956.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8764