TNF receptor-associated factor 3; CD40 receptor-associated factor 1; CRAF1; CD40-binding protein; CD40BP; LMP1-associated protein; LAP1; CAP-1 (TRAF3, CAP1, CRAF1)
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Function
- adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases
- thought to transmit signal of CD40
- seems to be involved in activation of NF-kappa-B & JNK & in apoptosis
- regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding
- seems to play a role T-cell dependent immune responses homotrimer (probable)
- heteromer with TRAF5
- binds to TNFRSF5/CD40
- associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF17/BCMA & EDAR, MAP3K5, MAP3K14, & TRAF-interacting protein TRIP & TRAF & TNF receptor-associated protein TTRAP
- binds to TANK/ITRAF & TRAF3IP1
- interacts with TICAM1 (putative)
- interacts with OTUD5
Structure
- the MATH/TRAF domain binds to receptor cytoplasmic domains
- contains 1 MATH domain
- contains 1 RING-type Zn+2 finger
- contains 2 TRAF-type Zn+2 fingers
Compartment
cytoplasm (probable)
More general terms
References
- ↑ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533327
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7187
- ↑ UniProt http://www.uniprot.org/uniprot/Q13114.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/TRAF3ID271.html