CD40 [CDw40], TNF receptor family member 5 (TNFRSF5), Bp50 or B-cell activation protein CD40
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Function
- B lymphocyte activation molecule
- CD40 is the receptor for CD40L or TRAP cytokine
- CD40 transduces a signal inhibiting apoptosis of the cell bearing the CD40 receptor
- stimulation of CD40 causes Tyr phosphorylation of multiple substrates including lyn
- activates multiple serine/threonine kinases & induces phosphorylation of PLC-gamma2 & PI-3-kinase[4]
- activation of CD40 by CD40L results in activation of bcl-x in B-cells inhibiting apoptosis[5]
- interacts with TRAF1, TRAF2, TRAF3, TRAF5 & TRAF6
Structure
Compartment
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing
named isoforms=2
Additional isoforms seem to exist
Expression
- B cells
- macrophages
- dendritic cells
- endothelial cells
- fibroblasts
- keratinocytes
- plasma cells stain negatively with antibody
Pathology
- expressed in:
- some carcinomas
- B cell lymphomas (most)
- B-ALL (some)
- defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3
More general terms
Additional terms
- B lymphocyte
- CD154; CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor ligand superfamily member 5 (CD40LG, CD40L TNFSF5, TRAP)
- dendritic cell
- epithelial cell
- macrophage
References
- ↑ Banchereau J et al Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science. 1991 Jan 4;251(4989):70-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1702555
- ↑ Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
- ↑ Nagata S, Golstein P. The Fas death factor. Science. 1995 Mar 10;267(5203):1449-56. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533326
- ↑ 4.0 4.1 Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533327
- ↑ 5.0 5.1 Wang Z, Karras JG, Howard RG, Rothstein TL. Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J Immunol. 1995 Oct 15;155(8):3722-5. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/7561075
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ UniProt http://www.uniprot.org/uniprot/P25942.html
- ↑ CD40base; Note: CD40 mutation db http://bioinf.uta.fi/CD40base/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD40
- ↑ Wikipedia; Note: CD40 entry http://en.wikipedia.org/wiki/CD40