CD154; CD40 ligand; CD40-L; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor ligand superfamily member 5 (CD40LG, CD40L TNFSF5, TRAP)
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Function
- delivers a contact-dependent signal that stimulates B-cell survival, growth & differentiation
- activation of CD40 by CD40L results in activation of bcl-x in B-cells inhibiting apoptosis[3]
- mediates B-cell proliferation without co-stimulus & IgE production in the presence of IL-4
- role in immunoglobulin class switching
- release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, & matrixmetalloproteinases (MMP) inhibitor-sensitive pathway
- soluble form derives from proteolytic processing
Structure
- N-linked glycan is a mixture of high mannose & complex type
- glycan structure does not influence binding affinity to CD40
- not O-glycosylated
- homotrimer
- belongs to the tumor necrosis factor family
Compartment
- cell membrane; single-pass type 2 membrane protein
- CD40 ligand, soluble form: secreted
Expression
- specifically expressed on activated CD4+ T-cells
- CD40L is found on lymphoid follicle CD4+ T-cells
Pathology
- defects in CD40L in humans is manifested in X-linked hyper IgM syndrome
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P29965.html
- ↑ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7533327
- ↑ 3.0 3.1 Wang Z, Karras JG, Howard RG, Rothstein TL. Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J Immunol. 1995 Oct 15;155(8):3722-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7561075
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=959
- ↑ CD40Lbase; Note: CD40L defect database http://bioinf.uta.fi/CD40Lbase/
- ↑ GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/CD40LG