matrixin or matrix metalloproteinase

Introduction

family of extracellular soluble or membrane bound proteases

Function

• involved in
  • remodelling of extracellular matrix
  • regulation of inflammatory and repair processes.
• substrates include:
  • structural proteins
  • proteases
  • clotting factors
  • growth factors
  • chemokines
  • cell surface receptors
  • adhesion molecules

Expression

• expressed in many cells including macrophages, fibroblasts, endothelial cells & most cancer cells

More general terms

• zinc metalloprotease
• secreted protein

More specific terms

• matrix metalloproteinase-10 (matrixin-10, stromelysin-2, transin-2, MMP10, STMY2)
• matrix metalloproteinase-11 (matrixin-11, stromelysin-3, transin-3, MMP11, STMY3)
• matrix metalloproteinase-13 (matrixin-13, collagenase-3, MMP13)
• matrix metalloproteinase-15 (matrixin-15, membrane-type matrix metalloproteinase 2, MTMMP2, MMP15, MT2MMP, SMCP-2)
• matrix metalloproteinase-16 (matrixin-16, membrane-type matrix metalloproteinase 3, MTMMP3, MMPX2 MMP16)
• matrix metalloproteinase-17; matrixin 17; MMP-17; membrane-type matrix metalloproteinase 4; MT-MMP 4; membrane-type-4 matrix metalloproteinase; MT4-MMP; Puente (MMP17, MT4MMP)
• matrix metalloproteinase-19; MMP-19; matrix metalloproteinase RASI; MMP-18 (MMP19, MMP18, RASI)
• matrix metalloproteinase-1; matrixin-1; interstitial collagenase; fibroblast collagenase (MMP1, CLG)
• matrix metalloproteinase-20; matrixin 20; enamel metalloproteinase; enamelysin (MMP20)
• matrix metalloproteinase-21; matrixin 21 (MMP21)
• matrix metalloproteinase-23; matrixin-23; MMP-23; matrix metallopeptidase 21; MMP-21; matrix metalloprotease 22; MMP-22; femalysin; MIFR-1 (MMP23A, MMP23B, MMP22)
• matrix metalloproteinase-24; MMP-24; membrane-type matrix metalloproteinase 5; MT-MMP 5;membrane-type-5 matrix metalloproteinase; MT5-MMP (MMP24, MT5MMP)
• matrix metalloproteinase-25; matrixin 25; membrane-type matrix metalloproteinase 6; leukolysin; membrane-type-6 matrix metalloproteinase; MT6-MMP (MMP25, MMPL1, MT6MMP)
• matrix metalloproteinase-26; matrixin 26; matrilysin-2; endometase (MMP26)
• matrix metalloproteinase-27; matrixin 27 (MMP27)
• matrix metalloproteinase-28; matrixin 28; epilysin (MMP28, UNQ1893/PRO4339)
• matrix metalloproteinase-3 (matrixin-3, stromelysin-1, transin-1, SL-1, MMP3, STMY1)
• matrix metalloproteinase-8 (matrixin-8, neutrophil collagenase, PMNL collagenase, PMNL-CL, MMP8, CLG1)
• matrixin elastase