matrix metalloproteinase-25; matrixin 25; membrane-type matrix metalloproteinase 6; leukolysin; membrane-type-6 matrix metalloproteinase; MT6-MMP (MMP25, MMPL1, MT6MMP)

Function

• may activate progelatinase A
• precursor is cleaved by a furin endopeptidase

Cofactor:

• binds 1 Zn+2 per subunit (putative)
• Ca+2 (putative)

Structure

• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
• belongs to the peptidase M10A family
• contains 4 hemopexin-like domains

Compartment

• cell membrane; lipid-anchor, GPI-anchor, extracellular side
• secreted, extracellular space, extracellular matrix

Expression

• expressed predominantly in leukocytes, lung & spleen

Pathology

• expressed also in colon carcinoma, astrocytoma & glioblastomas

More general terms

• matrixin or matrix metalloproteinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64386
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64386
• OMIM: https://mirror.omim.org/entry/608482
• UniProt: http://www.uniprot.org/uniprot/Q9NPA2.html