matrix metalloproteinase-23; matrixin-23; MMP-23; matrix metallopeptidase 21; MMP-21; matrix metalloprotease 22; MMP-22; femalysin; MIFR-1 (MMP23A, MMP23B, MMP22)

Function

• protease
• inhibited by TIMP2
• proteolytic cleavage might yield an active form

Structure

• belongs to the peptidase M10A family
• N-glycosylated
• contains 1 Ig-like C2-type domain (immunoglobulin-like domain)

Cofactor: binds 1 Zn+2 per subunit

Compartment

• membrane, cytoplasm, perinuclear region
• secreted form produced by proteolytic cleavage

Alternative splicing

named isoforms=3

Expression

expressed in ovary, testis, prostate

More general terms

• matrixin or matrix metalloproteinase

Database

• OMIM: https://mirror.omim.org/entry/603320
• OMIM: https://mirror.omim.org/entry/603321
• UniProt: http://www.uniprot.org/uniprot/O75900.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8511
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8510