matrix metalloproteinase-24; MMP-24; membrane-type matrix metalloproteinase 5; MT-MMP 5;membrane-type-5 matrix metalloproteinase; MT5-MMP (MMP24, MT5MMP)

Function

• activates progelatinase A
• may also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate & chondroitin sulfate proteoglycans
• partially cleaves fibronectin, but not collagen type 1, nor laminin (putative)
• precursor is cleaved by a furin endopeptidase

Cofactor:

• binds 1 Zn+2 per subunit (putative)
• Ca+2 (putative)

Structure

• the conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme
• dissociation of Cys from Zn+2 upon activation- peptide release activates the enzyme
• belongs to the peptidase M10A family
• contains 4 hemopexin-like domains

Compartment

• cell membrane; extracellular side (putative)
• processed form: secreted, extracellular space, extracellular matrix
• shed from cell surface as soluble proteinase, by a proteolytic cleavage (putative)

Expression

• predominantly expressed in brain, kidney, pancreas & lung

Pathology

• overexpressed in a series of brain tumors, including astrocytomas & glioblastomas

More general terms

• matrixin or matrix metalloproteinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10893
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10893
• OMIM: https://mirror.omim.org/entry/604871
• UniProt: http://www.uniprot.org/uniprot/Q9Y5R2.html