matrix metalloproteinase-11 (matrixin-11, stromelysin-3, transin-3, MMP11, STMY3)

Function

• role in the progression of epithelial malignancies (putative)
• precursor is cleaved by a furin endopeptidase

Cofactor:

• binds 1 Ca+2 per subunit (putative)
• binds 2 Zn+2 per subunit (putative)

Structure

• conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme; dissociation of the Cys from the Zn+2 upon the activation-peptide release activates the enzyme
• belongs to the peptidase M10A family
• contains 4 hemopexin-like domains

Expression

• specifically expressed in stromal cells of breast carcinomas

More general terms

• matrixin or matrix metalloproteinase

Database

• UniProt: http://www.uniprot.org/uniprot/P24347.html
• OMIM: https://mirror.omim.org/entry/185261
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4320
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4320