matrix metalloproteinase-15 (matrixin-15, membrane-type matrix metalloproteinase 2, MTMMP2, MMP15, MT2MMP, SMCP-2)

Function

• endopeptidase that degrades various components of the extracellular matrix
• may activate progelatinase A
• precursor is cleaved by a furin endopeptidase

Cofactor:

• binds 1 Zn+2 per subunit (putative)
• Ca+2 (putative)

Structure

• conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme;
• dissociation of the Cys from the Zn+2 upon the activation-peptide release activates the enzyme
• belongs to the peptidase M10A family
• contains 4 hemopexin-like domains

Compartment

membrane

Expression

• expressed in liver, placenta, testis, colon & intestine > pancreas, kidney, lung, heart & skeletal muscle

More general terms

• matrixin or matrix metalloproteinase
• membrane protein
• hydrolase

Database

• UniProt: http://www.uniprot.org/uniprot/P51511.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4324
• OMIM: https://mirror.omim.org/entry/602261
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4324