phospholipase C-gamma 2 (PLCG2, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2, PLC-4)

Function

• production of the second messenger molecules diacylglycerol & inositol 1,4,5-trisphosphate (IP3)
• crucial enzyme in transmembrane signaling
• phosphorylated on Tyr upon ligand-induced activation of a variety of growth factor receptors & immune system receptors
• Tyr phosphorylation increases phospholipase activity

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
                 <-->
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol

Cofactor: Ca+2

Structure

• contains 1 C2 domain
• contains 1 PH domain
• contains 1 PI-PLC X-box domain
• contains 1 PI-PLC Y-box domain
• contains 2 SH2 domains
• contains 1 SH3 domain

More general terms

• phospholipase C-gamma

Database

• UniProt: http://www.uniprot.org/uniprot/P16885.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5336
• OMIM: https://mirror.omim.org/entry/600220
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5336