hyper-IgM immunodeficiency syndrome (HIGM)

Pathology

• absence of Ig class switch recombination

Clinical manifestations

• profound susceptibility to bacterial infections

Laboratory

• normal or elevated serum IgM levels
• absence of serum IgG, serum IgA, & serum IgE

More general terms

• humoral immune dysfunction
• syndrome

More specific terms

• hyper-IgM immunodeficiency syndrome type 2 (HIGM2)
• hyper-IgM immunodeficiency syndrome type 3 (HIGM3)
• hyper-IgM immunodeficiency syndrome type 5 (HIGM5)
• hyper-IgM immunodeficiency syndrome type1; X-linked hyper IgM syndrome (HIGM1)