hyper-IgM immunodeficiency syndrome type 5 (HIGM5)

Pathology

• absence of Ig class switch recombination at a DNA precleavage step

Genetics

• associated with defects in UNG

Laboratory

• normal or elevated serum IgM levels
• absence of serum IgG, serum IgA, &serum IgE

More general terms

• hyper-IgM immunodeficiency syndrome (HIGM)

Database

• OMIM: https://mirror.omim.org/entry/608106