humoral immune dysfunction

Etiology

associated conditions

• multiple myeloma
• lymphoma
• splenectomy
• complement deficiency - properdin in males
• Bruton's X-linked agammaglobulinemia
• agammaglobulinemia
• chronic lymphocytic leukemia
• dysglobulinemia
• selective IgM deficiency
• selective IgA deficiency
• common variable immunodieficiency

Pathology

characteristic pathogens (recurrent infections)

• encapsulated bacteria*
  • Streptococcus pneumonia
  • Staphylococcus aureus
  • Haemophilus influenzae
  • Pseudomonas aeruginosa
  • Neisseria (complement deficiency, late components)
    • N. meningitidis
    • N. gonorrhoeae
• Mycoplasma
• Giardia lamblia
• Escherichia coli
• enteroviruses
• hepatitis virus

* recurrent pyogenic infection due to encapsulated organisms for which opsonization or complement mediated lysis is critical

Management

• pneumococcal & Haemophilus influenza B vaccine prior to splenectomy

More general terms

• immunodeficiency; immunodeficiency syndrome

More specific terms

• complement deficiency
• deficient antibody synthesis
• hyper-IgM immunodeficiency syndrome (HIGM)
• IgG subclass deficiency
• selective IgA deficiency
• selective IgM deficiency

Additional terms

• humoral immunity
• mixed cellular & humoral immune dysfunction