deficient antibody synthesis

Pathology

• deficiency in production of specific antibodies
• immunization with common vaccines fails to elicit protective response including
  • pneumovax
  • influenza vaccine
  • Haemophilus influenzae B vaccine
  • tetanus toxoid

Clinical manifestations

• frequent sinopulmonary infections

Laboratory

• serum protein electrophoresis shows normal serum immunoglobulin

More general terms

• humoral immune dysfunction