TNF receptor-associated factor 5; RING finger protein 84 (TRAF5 RNF84)

Function

• adapter protein & signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain & kinases
• mediates activation of NF-kappa-B & probably JNK
• seems to be involved in apoptosis
• homotrimer (probable)
• heteromer with TRAF3
• associates with TNFRSF5/CD40 through interaction with TRAF3
• associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, & TRAF & TNF receptor-associated protein TTRAP

Structure

• the MATH/TRAF domain binds to receptor cytoplasmic domains
• contains 1 MATH domain
• contains 1 RING-type Zn+2 finger
• contains 2 TRAF-type Zn+2 fingers

Compartment

cytoplasm (probable)

Expression

• expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, & peripheral blood

More general terms

• TRAF
• ring finger protein

Database

• OMIM: https://mirror.omim.org/entry/602356
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7188
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7188
• UniProt: http://www.uniprot.org/uniprot/O00463.html