tumor necrosis factor receptor superfamily member 13B; transmembrane activator & CAML interactor; CD267 (TNFRSF13B, TACI)
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Function
- receptor for TNFSF13/APRIL & TNFSF13B/TALL1/BAFF/BLYS
- binds both ligands with similar high affinity
- mediates calcineurin-dependent activation of NF-AT & activation of NF-kappa-B & AP-1
- role in stimulation of B-cell & T-cell function & in regulation of humoral immunity
- binds TRAF2, TRAF5 & TRAF6
- binds the NH2-terminal domain of CAMLG with its C-terminus
Structure
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
- highly expressed in spleen, thymus, small intestine & peripheral blood leukocytes
- expressed in resting B- cells & activated T-cells, but not in resting T-cells
Pathology
- defects in TNFRSF13B are a cause of
Laboratory
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O14836.html
- ↑ TNFRSF13Bbase; Note: TNFRSF13B mutation db http://bioinf.uta.fi/TNFRSF13Bbase/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=TNFRSF13B
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2349
- OMIM: https://mirror.omim.org/entry/240500
- OMIM: https://mirror.omim.org/entry/604907
- OMIM: https://mirror.omim.org/entry/609529
- UniProt: http://www.uniprot.org/uniprot/O14836.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23495