tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- & APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD256 (TNFSF13, APRIL, TALL2, ZTNF2, UNQ383/PRO715)

Function

• cytokine that binds to TNFRSF13B/TACI & to TNFRSF17/BCMA
• may be implicated in the regulation of tumor cell growth
• may be involved in monocyte/macrophage-mediated immunological processes
• the precursor is cleaved by furin

Structure

• homotrimer (putative)
• belongs to the tumor necrosis factor family

Compartment

secreted

Alternative splicing

named isoforms=3; alpha, beta, gamma

Expression

• expressed at high levels in transformed cell lines, colon carcinoma, thyroid carcioma, & lymphoma
• specifically expressed in monocytes & macrophages
• down-regulated by phorbol myristate acetate/ionomycin treatment

More general terms

• tumor necrosis factor (TNF) family protein
• glycoprotein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8741
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8741
• OMIM: https://mirror.omim.org/entry/604472
• UniProt: http://www.uniprot.org/uniprot/O75888.html