tumor necrosis factor receptor superfamily member 19; Toxicity & JNK inducer; TRADE (TNFRSF19, TAJ, TROY, UNQ1888/PRO4333)

Function

• can mediate activation of JNK & NF-kappa-B
• may promote caspase-independent cell death
• associates with TRAF1, TRAF2, TRAF3 & TRAF5
• interacts with LINGO1

Structure

contains 3 TNFR-Cys repeats

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in prostate
• detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon & peripheral blood leukocytes

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5550
• OMIM: https://mirror.omim.org/entry/606122
• UniProt: http://www.uniprot.org/uniprot/Q9NS68.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55504