leucine-rich repeat & immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (leucine-rich repeat & immunoglobilin-domain containing protein 1, leucine-rich repeat neuronal protein 6A, leucine-rich repeat neuronal protein 1, LINGO1, LERN1, LRRN6A, UNQ201/PRO227)
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Function
- functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors
- negative regulator of oligodentrocyte differentiation & axonal myelination
- N-glycosylated. contains predominantly high-mannose glycans
Structure
- homotetramer
- forms ternary complex with RTN4R/NGFR & RTN4R/TNFRSF19
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 13 LRR repeats (leucine-rich repeats)
Compartment
Alternative splicing
named isoforms=2
Expression
- expressed exclusively in the central nervous system
- highest level in the in amygdala, hippocampus, thalamus & cerebral cortex
- in the rest of the brain a basal expression seems to be always present
Pathology
- up-regulated in substantia nigra neurons from patients with Parkinson's disease
More general terms
- leucine-rich repeat & immunoglobulin-like domain-containing nogo receptor-interacting protein
- glycoprotein
- phosphoprotein