reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor (RTN4R, NOGOR, UNQ330/PRO526)
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Function
- receptor for RTN4, OMG & MAG
- mediates axonal growth inhibition
- may play a role in regulating axonal regeneration & plasticity in the adult central nervous system
- interacts with LINGO1
Structure
- homomultimer
- belongs to the Nogo receptor family
- contains 9 LRR repeats (leucine-rich repeats)
Compartment
cell membrane; lipid-anchor, GPI-anchor
Expression
- widespread in the brain
- highest levels in gray matter
- low levels in heart & kidney
- not expressed in oligodendrocytes (white matter)
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9BZR6.html
- ↑ Protein Spotlight; Note: nerve regrowth: nipped by a no-go
Issue 69 of April 2006 http://www.expasy.org/spotlight/back_issues/sptlt069.shtml - ↑ Fournier AE et al Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409:341-346, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11201742
- ↑ Liu BP et al Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor Science 297:1190-3, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12089450