myelin-associated glycoprotein; siglec-4a (MAG GMA)
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Function
- adhesion molecule in postnatal neural development
- mediates sialic-acid dependent cell-cell interactions between neuronal & myelinating cells (oligodendrocytes)
- preferentially binds to alpha-2,3-linked sialic acid (putative)
- binds to RTN4R (putative)
Structure
- belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
- contains 4 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment
membrane
Pathology
- IgM monoclonal antibody binds to MAG in ~50% of patients with MGUS
More general terms
References
- ↑ Schachner M, Martini R. Glycans and the modulation of neural-recognition molecule function. Trends Neurosci. 1995 Apr;18(4):183-91. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7539963
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4099
- ↑ UniProt http://www.uniprot.org/uniprot/P20916.html
- ↑ Functional glycomics gateway - glycan binding Note: siglec-4 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_271
- ↑ ARUP laboratories Anti-MAG and Anti-SGPG, IgM SERODIAGNOSIS OF AUTOIMMUNE NEUROPATHIES http://www.aruplab.com/Testing-Information/resources/TechnicalBulletins/Anti-MAG%20and%20Anti-SGPG,%20IgM.pdf